Health risk of chrysotile

This review provides a basis for substantiating both kinetically and pathologically the differences between chrysotile and amphibole asbestos.

Recent scientific studies have contributed to a more complete understanding of the health risk from chrysotile asbestos as used today in high-density products. Key to understanding this is the differentiation of exposure, dose and response of the serpentine mineral chrysotile in comparison to the amphibole asbestos types such as crocidolite, tremolite and amosite. This research reviews scientific studies identified as chrysotile only or predominately chrysotile and discusses how the newer toxicological and epidemiological data provide a convergence in the understanding of the risk from chrysotile.

The study found that chrysotile, which is rapidly attacked by the acid environment of the macrophage, falls apart in the lung into short fibers and particles, while the amphibole asbestos persist creating a response to the fibrous structure of this mineral. Inhalation toxicity studies of chrysotile at non-lung overload conditions demonstrate that the long (420 mm) fibers are rapidly cleared from the lung, are not translocated to the pleural cavity and do not initiate fibrogenic response. In contrast, long amphibole asbestos fibers persist, are quickly (within 7 d) translocated to the pleural cavity and result in interstitial fibrosis and pleural inflammation.

Download Attachments


Newer Posts